Additive protective effects of estrogen and androgen treatment on trabecular bone in ovariectomized rats

By Asa Tivesten, Sofia Movérare-Skrtic, Andrei Chagin, Katrien Venken, Phil Salmon, Dirk Vanderschueren, Lars Sävendahl, Agneta Holmäng, Claes Ohlsson

Abstract

Both ER and AR activation regulates trabecular bone mass. We show that combined estrogen and androgen treatment results in additive protection of trabecular bone in OVX rats. This may in part be attributable to the effect of AR activation to attenuate the inhibitory effect of ER activation on bone formation... (Read Full Article)

https://pubmed.ncbi.nlm.nih.gov/15476584/

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