Overview: An analysis of excess deaths among women with hysterectomies aged 50 to 59 years, this study examined the effect of estrogen avoidance on mortality rates.
The effect of estrogen avoidance on mortality rates among hysterectomized women aged 50 to 59 years was examined.
A formula was derived to relate the excess mortality among hysterectomized women aged 50 to 59 years assigned to placebo in the Women’s Health Initiative randomized controlled trial to the entire population of comparable women in the United States, incorporating the decline in estrogen use observed between 2002 and 2011.
Over a span of 10 years, starting in 2002, a minimum of 18,601 and as many as 91,610 postmenopausal women died prematurely because of the avoidance of estrogen therapy (ET).
ET in younger postmenopausal women is associated with a decisive reduction in all-cause mortality, but estrogen use in this population is low and continuing to fall. The data indicates an associated annual mortality toll in the thousands of women aged 50 to 59 years. Informed discussion between these women and their healthcare providers about the effects of ET is a matter of considerable urgency.